Ovarian cancer causes around 266 women to lose their lives from this disease each year in Ireland. This project will investigate chemotherapy resistance in ovarian cancer
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Aim is to further understand personalised disease mechanisms and treatment in Uveal melanoma (UM)
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The gut microbiota impacts health, and its disruption is potentially related to multiple diseases, including cancer. This project will generate knowledge on the impact of gut microbiota on cancer
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Precision Oncology Ireland is a consortium of 5 Irish Universities, 6 Irish Charities, and 10 companies aiming to develop new diagnostics and therapeutics for the personalised treatment of cancer.
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To investigate the role of cancer-related genes among patients with Glioblastoma multiforme, who are and are not extreme responders to chemotherapy; to improve understanding the disease
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To develop and coordinate a multi-disciplinary nurse-led survivorship clinic and symptom management pathway which integrates hospital and community services.
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This research will analyse blood samples from patients with newly diagnosed small cell lung cancer to risk stratify patients and potentially identify new targeted treatments.
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Investigating a novel aspect of cancer biology with the potential to improve ovarian patient outcomes. A major challenge in the clinical management of Ovarian Cancer is the high rate of reoccurrence.
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Prof Merete Haedersdal in collaboration with Dr Soden are working to develop a more effective method for treating skin cancers, using electroporation.
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Breakthrough/Charlie Fell Fellowship recipient's pre-clinical work instrumental in 3 Investigator initiated trials opening soon for pancreatic cancer in Willmott Cancer Institute.
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Fiona O'Connell was awarded the Musgrave PhD Scholarship for her project: Radiation Response in Oesophageal Cancer: the role of visceral fat tissue in controlling response through immune-meta
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Roisin Cassidy was awarded a Breakthrough PhD Scholarship for her project: Chemosensitisation of oesophageal squamous cell carcinoma using epigenetic modifiers and cytotoxic drug polytherapy.
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Eimear Mylod was awarded a Breakthrough PhD Scholarship for her project: Harnessing the power of the immune system to fight obesity associated cancer. This research, is under the supervision
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This project is investigating how effective non-toxic compounds in combination with electrochemotherapy are against melanoma, and it is working to understand their effect on a cellular level
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Overcoming pancreatic cancer resistance by using electroporation.
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Investigation of the impact of a Mindfulness Based Stress Reduction (MBSR) programme on the quality of life of people living with secondary cancer.
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In Ireland there is a shortage of dietitians, cancer patients need expert nutritional advice and treatment. Often people with cancer to seek out information themselves.
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Lifestyle factors including diet, physical inactivity, smoking and alcohol consumption and high body mass index (BMI) are known to contribute to cancer risk. 42-45% of cancers could be prevented.
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The aim of this project is to identify new ways of targeting resistant cancers, so that chemotherapeutic regimes can be improved and recurrent disease eliminated in cancer patients.
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We will examine the use of electric pulses to aid in the delivery to drugs to tumour tissue. Short electric pulses have been demonstrated to make tissue temporarily more porous.
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Our work will position our drug along a pathway where it could eventually be given to oesophageal patients alongside standard CRT to make tumours respond and result in better outcomes for these ca
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The development of evidence based resources for cancer patients to help with improving their oral intake during treatment and supporting patient recovery in the survival stage.
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Epigenetic therapy is being studied as a way to alter cancer cell growth, migration, and increased sensitivity to cytotoxic drugs for the treatment of oesophageal cancer.
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EValuation of the impact of emotional, nutritional & physical exercise support interventions delivered by a volunteer-led Cancer Support centre, on unmet needs & health related QOL of cancer patients.
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This project proposes to expand upon treatment regimens of poor prognosis cancers by developing the electroporation treatment of osteosarcoma cancer.
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This project evaluates the effect of stemness and resistance to electroporation delivered treatments in relation to pancreatic cancer
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A novel treatment regime, which could lead to the induction of both autophagy and differentiation in cells derived from Acute Myeloid Leukaemia (AML)has been identified
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Investigating resistance mechanisms in oesophageal cancer cells has shown that a recycling process within cancer cells (called Autophagy) can help cells recover from chemotherapy.
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Deeper understanding of the bacteria that live in our body is enabling identification of i) potential causes of and ii) potential treatments for disease.
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Due to the poor survival of women with recurrent, chemoresistant ovarian cancer, Breakthrough believe that a greater understanding of the mechanisms which contribute to this resistance is urgent.
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