Overcoming pancreatic cancer resistance by using electroporation.
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The aim of this project is to identify new ways of targeting resistant cancers, so that chemotherapeutic regimes can be improved and recurrent disease eliminated in cancer patients.
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We will examine the use of electric pulses to aid in the delivery to drugs to tumour tissue. Short electric pulses have been demonstrated to make tissue temporarily more porous.
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Our work will position our drug along a pathway where it could eventually be given to oesophageal patients alongside standard CRT to make tumours respond and result in better outcomes for these ca
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The development of evidence based resources for cancer patients to help with improving their oral intake during treatment and supporting patient recovery in the survival stage.
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Epigenetic therapy is being studied as a way to alter cancer cell growth, migration, and increased sensitivity to cytotoxic drugs for the treatment of oesophageal cancer.
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EValuation of the impact of emotional, nutritional & physical exercise support interventions delivered by a volunteer-led Cancer Support centre, on unmet needs & health related QOL of cancer patients.
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Investigating epigenetic drug-induced re-expression of tumour suppressor genes which may influence future optimal treatment strategies and predict responses in oesophageal cancer patients.
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This project proposes to expand upon treatment regimens of poor prognosis cancers by developing the electroporation treatment of osteosarcoma cancer.
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This project evaluates the effect of stemness and resistance to electroporation delivered treatments in relation to pancreatic cancer
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A novel treatment regime, which could lead to the induction of both autophagy and differentiation in cells derived from Acute Myeloid Leukaemia (AML)has been identified
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Investigating resistance mechanisms in oesophageal cancer cells has shown that a recycling process within cancer cells (called Autophagy) can help cells recover from chemotherapy.
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Deeper understanding of the bacteria that live in our body is enabling identification of i) potential causes of and ii) potential treatments for disease.
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