Recent/Currently Funded Projects

Enhancing electroporation delivery for pancreatic cancer

Overcoming pancreatic cancer resistance by using electroporation.

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Evaluation of the role of MxA and ISGylation in chemosensitivity in oesophageal cancer

The aim of this project is to identify new ways of targeting resistant cancers, so that chemotherapeutic regimes can be improved and recurrent disease eliminated in cancer patients.

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Combining electrochemotherapy with a Toll Like receptor agonist for the treatment of lung cancer

We will examine the use of electric pulses to aid in the delivery to drugs to tumour tissue. Short electric pulses have been demonstrated to make tissue temporarily more porous.

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Gold-drug: Targeting a novel dual inhibitor drug with gold nanoparticles for improving radiation response in oesophageal cancer

Our work will position our drug along a pathway where it could eventually be given to oesophageal patients alongside standard CRT to make tumours respond and result in better outcomes for these ca

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The role of diet, nutritional assessment and intervention in the prevention of cancer and the treatment of cancer-related malnutrition.

The development of evidence based resources for cancer patients to help with improving their oral intake during treatment and supporting patient recovery in the survival stage.

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Epigenetic modulating compounds as potential therapeutic agents for oesophageal cancer management.

Epigenetic therapy is being studied as a way to alter cancer cell growth, migration, and increased sensitivity to cytotoxic drugs for the treatment of oesophageal cancer.

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The EVeCanS Study

EValuation of the impact of emotional, nutritional & physical exercise support interventions delivered by a volunteer-led Cancer Support centre, on unmet needs & health related QOL of cancer patients.

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Epigenetic Modulating Compounds as Potential Therapeutic Agents for Treatment of Oesophageal Cancer.

Investigating epigenetic drug-induced re-expression of tumour suppressor genes which may influence future optimal treatment strategies and predict responses in oesophageal cancer patients.

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Osteosarcoma – Combination of Electroporation of Metabolic Modulators with Low dose chemotherapy

This project proposes to expand upon treatment regimens of poor prognosis cancers by developing the electroporation treatment of osteosarcoma cancer.

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Pancreatic cancer – Stemness and Resistance to Treatments such as Electroporation/Electrochemotherapy

This project evaluates the effect of stemness and resistance to electroporation delivered treatments in relation to pancreatic cancer

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Role of Autophagy in Differentiation Therapy in AML

A novel treatment regime, which could lead to the induction of both autophagy and differentiation in cells derived from Acute Myeloid Leukaemia (AML)has been identified

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Role of Autophagy in Progression of Oesophageal Cancer

Investigating resistance mechanisms in oesophageal cancer cells has shown that a recycling process within cancer cells (called Autophagy) can help cells recover from chemotherapy.

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Bacteria in Human Tumours

Deeper understanding of the bacteria that live in our body is enabling identification of i) potential causes of and ii) potential treatments for disease.

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