Breakthrough Cancer Research Donate

Measuring genetic markers in the blood of patients with small cell lung cancer

By: Dr Frances Drummond | Posted on: 18 Mar 2020

Measuring genetic markers in the blood of patients with small cell lung cancer
Dr Dearbhaile Collins

   

Start year: 2020

Principal Investigators: Dr Dearbhaile Collins

Host Institution: Cork University Hospital and The Institute of Cancer Research, Royal Marsden Hospital Trust, London 

Cancer type: Small Cell Lung Cancer

Linked Breakthrough Research Priorities: 1, 5

 

Patients with small cell lung cancer have a very poor prognosis.  Almost 1 in 3 of these patients     have a higher number of the oncogene i.e. a gene, or piece of DNA that can potentially cause cancer, called MYC.  The oncogene MYC has been reported to correlate with a more aggressive form of small cell lung cancer, and lower overall survival.

 

This research project is a collaboration between Cork University Hospital and the Institute of Cancer Research, Royal Marsden Hospital Trust, London.  The research team will collect blood samples from patients when they are first diagnosed with small cell lung cancer, before they start anti-cancer treatment.  The patient blood samples will be analysed for the MYC oncogene.  Using blood samples instead of tumour biopsy minimises potential harm to patients.

 

It is hoped that this research will help to identify patients with different risks of small cell lung cancer progression, and to potentially identify new targeted treatment approaches for patients.  This research will also increase our understanding of the role of the MYC oncogene in small cell lung cancer.

 

© Site Designed by Granite Digital