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Evaluation of the Therapeutic and Adverse Potential Cannabinoids in vision and Uveal Melanoma

Posted on: 14 Oct 2020

Evaluation of the Therapeutic and Adverse Potential Cannabinoids in vision and Uveal Melanoma
Marzia Pendino

Start year: 2020

Principal Investigator: Prof Breandán N Kennedy

Institution: UCD Conway Institute, University College Dublin

Grant funding: Irish Research Council Enterprise Partnership Scheme (Postgraduate) grant with Breakthrough cancer Research as the Enterprise Partner

Linked Breakthrough Research Priorities: 1, 2, 3, 4, 5

 

Marzia Pendino was awarded an Irish Research Council Enterprise Partnership Scheme (Postgraduate) grant with Breakthrough cancer Research as the Enterprise Partner

This project investigates the therapeutic potential of cannabinoids in vision and uveal melanoma (UM).  UM is a rare cancer of the eye.  In approximately 50% of cases, liver metastasizes occurs which decreases life expectancy.  Ireland has one of the highest UM incidences worldwide.

During her 4 year PhD, Marzia will analyse the expression of cannabinoid CB1 & CB2 receptors in human UM cells lines and patient/xenograft samples. She will test if cannabinoid drugs modulate cancer hallmarks (proliferation, metabolism, angiogenesis) in human primary/metastatic UM cell lines and zebrafish xenografts. Marzia will also determine if cannabinoids can restore vision in zebrafish models of blindness. This study will potentially lead to new therapies for UM.

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